With nearly 11 million treatments, find out if its right for you.  BOTOX® Cosmetic is a prescription medicine that is injected into muscles and used to improve the look of moderate to severe frown lines between the eyebrows, crows feet, and other facial fine lines.  It works by blocking nerve impulses to the injected muscles.   To learn more about BOTOX® Cosmetic, click here.   New BOTOX® Cosmetic client?  Print this page and bring it to your appointment for $25 off! For a limited time, all clients can also receive $50 off a dual treatment of both BOTOX® Cosmetic and JUVÉDERM® XC! Scroll down for important safety information.                        As you age, your skin changes.  For example, it reduces production of a naturally hydrating substance called hyaluronic acid (HA).  Over time, the loss of HA in your skin results in facial wrinkles and folds, like those "parentheses" lines around your mouth.   JUVÉDERM® XC  injectable gel replaces the HA your skin has lost, bringing back its volume and smoothing away facial wrinkles and folds.  A breakthrough in HA dermal fillers, JUVÉDERM® XC is the first smooth-consistency HA gel and the only HA filler that's FDA approved to last up to one year.   JUVÉDERM® XC injectable gel is now formulated with lidocaine, a common anesthetic used to improve the comfort of treatment.   To learn more about JUVÉDERM® XC injectable gel, click here.    New JUVÉDERM® XC client?  Print this page and bring it to your appointment for $25 off! For a limited time, all clients can also receive $50 off a dual treatment of both BOTOX® Cosmetic and JUVÉDERM® XC!

Indication
BOTOX^® Cosmetic is indicated for the temporary improvement in the appearance of moderate to severe glabellar lines associated with corrugator and/or procerus muscle activity in patients 18 to 65 years of age.

Distant Spread of Toxin Effect
Postmarketing reports indicate that the effects of BOTOX^® Cosmetic and all botulinum toxin products may spread from the area of injection to produce symptoms consistent with botulinum toxin effects. These may include asthenia, generalized muscle weakness, diplopia, blurred vision, ptosis, dysphagia, dysphonia, dysarthria, urinary incontinence, and breathing difficulties. These symptoms have been reported hours to weeks after injection. Swallowing and breathing difficulties can be life threatening, and there have been reports of death. The risk of symptoms is probably greatest in children treated for spasticity, but symptoms can also occur in adults treated for spasticity and other conditions, particularly in those patients who have underlying conditions that would predispose them to these symptoms. In unapproved uses, including spasticity in children and adults, and in approved indications, cases of spread of effect have occurred at doses comparable to those used to treat cervical dystonia and at lower doses.

CONTRAINDICATIONS
BOTOX^® Cosmetic is contraindicated in the presence of infection at the proposed injection site(s) and in individuals with known hypersensitivity to any botulinum toxin preparation or to any of the components in the formulation.

WARNINGS
The recommended dosage and frequency of administration for BOTOX^® Cosmetic should not be exceeded. Risks resulting from administration at higher dosages are not known.

Lack of Interchangeability Between Botulinum Toxin Products
The potency Units of BOTOX^® Cosmetic are specific to the preparation and assay method utilized. They are not interchangeable with other preparations of botulinum toxin products and, therefore, Units of biological activity of BOTOX^® Cosmetic cannot be compared to or converted into Units of any other botulinum toxin products assessed with any other specific assay method.

Spread of Toxin Effect
Please refer to Boxed Warning for Distant Spread of Toxin Effect.

No definitive, serious adverse event reports of distant spread of toxin effect associated with dermatologic use of BOTOX^® Cosmetic at the labeled dose of 20 Units (for glabellar lines) have been reported.

Hypersensitivity Reactions
Serious and/or immediate hypersensitivity reactions have been reported. These reactions include anaphylaxis, urticaria, soft-tissue edema, and dyspnea. If such reactions occur, further injection of BOTOX^® Cosmetic should be discontinued and appropriate medical therapy immediately instituted. One fatal case of anaphylaxis has been reported in which lidocaine was used as the diluent and, consequently, the causal agent cannot be reliably determined.

Pre-existing Neuromuscular Disorders
Individuals with peripheral motor neuropathic diseases, amyotrophic lateral sclerosis, or neuromuscular junctional disorders (eg, myasthenia gravis or Lambert-Eaton syndrome) should be monitored particularly closely when given botulinum toxin. Patients with neuromuscular disorders may be at increased risk of clinically significant effects including severe dysphagia and respiratory compromise from typical doses of BOTOX^® Cosmetic.

PRECAUTIONS
Caution should be used when BOTOX^® Cosmetic treatment is used in patients who have an inflammatory skin problem at the injection site, marked facial asymmetry, ptosis, excessive dermatochalasis, deep dermal scarring, thick sebaceous skin, or the inability to substantially lessen glabellar lines by physically spreading them apart.

Information for Patients
Patients should be counseled that if loss of strength, muscle weakness, or impaired vision occur, they should avoid driving a car or engaging in other potentially hazardous activities.

Pregnancy
Administration of BOTOX^® Cosmetic is not recommended during pregnancy. There are no adequate and well-controlled studies of BOTOX^® Cosmetic in pregnant women.

Nursing Mothers
It is not known whether BOTOX^® Cosmetic is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when BOTOX^® Cosmetic is administered to a nursing woman.

ADVERSE REACTIONS
General
The most serious adverse events reported after treatment with botulinum toxin include spontaneous reports of death, sometimes associated with anaphylaxis, dysphagia, pneumonia, and/or other significant debility.

There have also been reports of adverse events involving the cardiovascular system, including arrhythmia and myocardial infarction, some with fatal outcomes. Some of these patients had risk factors including pre-existing cardiovascular disease.

The most frequently reported adverse events following injection of BOTOX^® Cosmetic include blepharoptosis and nausea.

Overdosage
Excessive doses of BOTOX^® Cosmetic may be expected to produce neuromuscular weakness with a variety of symptoms. Respiratory support may be required where excessive doses cause paralysis of respiratory muscles. In the event of overdose, the patient should be medically monitored for symptoms of excessive muscle weakness or muscle paralysis.

In the event of suspected or actual overdosage, please contact your local or state health department to process a request for antitoxin through the Centers for Disease Control and Prevention (CDC). If you do not receive a response within 30 minutes, please contact the CDC directly at 1-770-488-7100.

Please see BOTOX^® Cosmetic full Prescribing Information including Medication Guide.